From phage to medication: phagotherapy
Phage therapy has been applied for decades to treat bacterial infections, first by Pasteur Institute in France, then in Georgia and Russia. The advent of antibiotics during the second world war led to a significant reduction of phage therapy, except in Eastern and Central Europe.
Because of the rise of antibiotic-resistant bacteria and the dramatic health crisis it generates, new approaches are needed. Phage therapy is one of the most advanced and promising alternatives.
Phages properties allow many different potential usages: Their high specificity and their biological nature allow their application to various fields: therapeutics, diagnostics, prophylaxy in medicine, agriculture, food processing and/or environmental applications; Pherecydes Pharma focuses in the developoment of phage treatments of bacterial infections.
Phages do display critical advantages:
- They are very effective to kill bacteria, including antibiotic-resistant ones,
- They are highly specific and thus preserve the natural bacterial flora (microbiote) which plays a major role in health as is being demonstrated everyday
- They are very well tolerated
- They can adapt very rapidly to new bacterial resistance forms and thus become effective again.
Pherecydes Pharma has chosen to develop individualized phage treatments, which can be related to personalized medicine and/or precision medicine: each treatment is designed according to the results of a preliminary analysis of the bacteria sensitivity to Pherecydes Pharma phages.The choice of the phages to be administered is determined according to this phage testing or "phagogramme". This focus the use of phages on only the active ones.
To simply understand phage therapy
Julien Ménielle hosts the YouTube channel "Dans ton corps" and has produced in partnership with the European Commission this clip which focuses on antimicrobial resistance, bacteriophages and Pherecydes Pharma's research to develop and produce new drugs (french content).