Pherecydes Pharma and BIOASTER join forces to explore the use of phage therapy to treat complicated urinary tract infections

LOGO PhagUTI

Pherecydes Pharma and BIOASTER, the French Technology Research Institute (TRI) for Microbiology and Infectious Diseases, announced the signing of a collaboration agreement.

This project, called PhagUTI, is a unique opportunity for the partners to capitalize on BIOASTER’s unique expertise in pre-clinical models and the extensive experience of Pherecydes in the selection, characterization and production of bacteriophages.

In the last few decades, antibiotics have turned life-threatening diseases into short-term disorders and have had a major positive impact on public health and the global economy. Today, however, this progress is under serious threat due to the rapidly increasing emergence of antibiotic resistance.

Worldwide, an estimated 700,000 resistant infections occur in hospitals annually. A recently published report forecasts that this could lead to 10 million deaths per year by 2050 and a cumulative cost over $100 trillion. Moreover, the widespread resistance to antibiotics threatens the most common medical and surgical procedures in modern medicine that it would no longer be possible to perform.

The increasing threat of resistance to existing antibiotics has been the major driver in the renewed interest in bacteriophages treatment; phages being the natural predators of bacteria.

E. coli is the main pathogen responsible for Urinary Tract Infections (UTI), in particular catheter-associated UTI (CAUTI) and Pyelonephritis. The objective of this project is to demonstrate the in vivo efficacy of phage therapy to treat urinary tract E. coli infections.

Pherecydes Pharma

“This project will be an important step forward for phage therapy and a new hope for patients,” commented Guy-Charles Fanneau de la Horie, CEO of Pherecydes Pharma. “We are looking forward to working with BIOASTER on this fascinating project,” he added.

BIOSTER

“This collaborative program illustrates BIOASTER’s ambition very well; bringing together partners’ complementary expertise for accelerating innovation towards new effective solutions for the patients,” said Nathalie Garçon, CEO & CSO of BIOASTER. “We are very proud to be part of this exciting project with Pherecydes that will generate new avenues for alternative treatments of multi-drug resistant bacterial infections.”